TRICHOSTATIN A STABILIZES THE EXPRESSION OF PLURIPOTENT GENES IN HUMAN MESENCHYMAL STEM CELLS DURING EX VIVO EXPANSION.

Trichostatin A stabilizes the expression of pluripotent genes in human mesenchymal stem cells during ex vivo expansion.

BACKGROUND: Mesenchymal stem cells (MSCs) have been considered as ideal cells for the treatment of a variety of diseases.However, aging and spontaneous differentiation of MSCs during culture expansion dampen their effectiveness.Previous studies suggest that ex vivo aging of MSCs is largely caused by epigenetic changes particularly a decline of hist

read more

An Optimal Family of Block Techniques to Solve Models of Infectious Diseases: Fixed and Adaptive Stepsize Strategies

The contemporary scientific community is very familiar with implicit block techniques for solving initial value problems in ordinary differential equations.This is due to the fact that these techniques are cost effective, consistent and stable, and they typically converge quickly when applied to solve particularly stiff models.These aspects of bloc

read more